![]() 640: Cell-free DNA Screening for Fetal Aneuploidy. Accessed January 28, 2015.Ħ Committee Opinion No. National Society of Genetic Counselors (NSGC) and Perinatal Quality Foundation (PQF). NIPT Cell Free DNA Screening Predictive Value Calculator. 2011 31(1):7-15.ĥ The American Congress of Obstetricians and Gynecologists. Screening for fetal aneuploidies at 11 to 13 weeks. DNA sequencing versus standard prenatal aneuploidy screening. 4 ed: Oxford University Press 2012:403-416.ģ Bianchi DW, Parker RL, Wentworth J, et al. Chromosome abnormalities and genetic counseling. Parental age counseling and screening for fetal trisomy. 2012.Ģ Gardner RJM, Sutherland GR, Shaffer LG. Analytical Validation of the verifi prenatal test: Enhanced Test Performance for Detecting Trisomies 21, 18, and 13 and the Option for Classification of Sex Chromosome Status. Counsel the patient about the NIPT results, the likelihood of a true positive (PPV), and the recommendation for confirmatory diagnostic testing 6ġ Illumina.To calculate a patient’s individual PPV, you may wish to use the PPV calculator endorsed by ACOG 5.PPVs calculated using verifi and first trimester combined screening sensitivities and specificities 1,4 and published prevalence estimates of trisomy 21, trisomy 18, and trisomy 13 at 10 weeks gestation for different maternal ages 2.įor patients with a positive NIPT result: PPV is based on the sensitivity and specificity of the test AND the prevalence of the condition in the population being tested. maternal age, ultrasound findings, etc) Performance Metrics Considerations After ScreeningĪ test’s PPV can help you determine how likely a positive result is to be a true positive versus a false positive. As such, they are not expected to change significantly based on an individual patient’s clinical picture (e.g. ![]() Sensitivity and specificity are test specific, not patient specific. verifi Sensitivity and Specificity for XX, XY and Monosomy X (MX) 1 Sex Chromosome Classification verifi Sensitivity and Specificity for Chromosomes 21, 18 and 13 1 Chromosome
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